Ribonucleoside-Diphosphate Reductase-M2 Chain

Cancer Terms -> Gene Product -> Protein -> Protein Complex Subunit -> Ribonucleotide Reductase Subunit -> Ribonucleoside-Diphosphate Reductase-M2 Chain

Ribonucleoside-Diphosphate Reductase-M2 Chain Definition

Ribonucleoside-Diphosphate Reductase M2 Chain, encoded by the RRM2 gene, is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)

Ribonucleoside-Diphosphate Reductase-M2 Chain Synonyms

Ribonucleoside-Diphosphate Reductase M2 Chain, EC 1.17.4.1, R2, RR2, RRM2, RRM2 Protein, Ribonucleotide Reductase M2 Polypeptide, Ribonucleotide Reductase Small Chain, Ribonucleotide Reductase, M2 Subunit, Ribonucleotide Reductase, R2 Subunit, Ribonucleotide Reductase, Small Subunit

Terms in Ribonucleoside-Diphosphate Reductase-M2 Chain category

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