Cancer Terms

Ribosomal Protein-L7A

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Ribosomal Protein-L7A Definition

Encoded by human RPL7A Gene (L7AE Family), 265-aa 30-kDa Ribosomal Protein L7a is a component of the large 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. (NCI)

Ribosomal Protein-L7A Synonyms

Ribosomal Protein L7a, 60S Ribosomal Protein L7a, PLA-X Polypeptide, RPL7A, SURF3, Surfeit 3, Surfeit Locus Protein 3, TRUP, Thyroid Hormone Receptor Uncoupling Protein

Terms in Ribosomal Protein-L7A category



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