Ribosomal Protein-S6 Kinase Alpha-5
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Ribosomal Protein-S6 Kinase Alpha-5 Definition
Widely expressed in heart, brain, placenta, lung, kidney, and liver by human RPS6KA5 Gene (S6 Ser/Thr Kinase Family), predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5 is a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI)
Ribosomal Protein-S6 Kinase Alpha-5 Synonyms
Ribosomal Protein S6 Kinase Alpha 5, 90 kDa Ribosomal Protein S6 Kinase 5, Mitogen- and Stress-Activated Protein Kinase 1, Nuclear Mitogen-and Stress-Activated Protein Kinase-1, RLSK, RPS6KA5, RSK-Like Protein Kinase, Ribosomal Protein S6 Kinase 90kD Polypeptide 5
Terms in Ribosomal Protein-S6 Kinase Alpha-5 category
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