Cancer Terms

Ro 31-7453

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimitotic Agent -> Tubulin Binding Agent -> Ro 31-7453

Ro 31-7453 Definition

An orally active bisindolylmaleimide and an inhibitor of cyclin dependent kinases with potential antineoplastic activity. MKC-1, as well as its metabolites, inhibits tubulin polymerization, thereby blocking the formation of the mitotic spindle leading to cell cycle arrest at the G2/M phase. In addition, this agent inhibits several cyclin-dependent kinases that regulate cell cycle progression, thereby causing cell cycle arrest and triggering apoptosis.

Ro 31-7453 Synonyms

MKC-1, R440, Ro 31-7453

Terms in Ro 31-7453 category



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