Cancer Terms

Rubitecan

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> Camptothecin Analogue -> Rubitecan

Rubitecan Definition

A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)

Rubitecan Synonyms

Rubitecan, 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, Camptogen, Nitrocamptothecin, Orathecin, RFS 2000, nitrocamptothecin

Terms in Rubitecan category



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