Rubitecan
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Camptothecin Analogue -> Rubitecan
Rubitecan Definition
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)
Rubitecan Synonyms
Rubitecan, 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, Camptogen, Nitrocamptothecin, Orathecin, RFS 2000, nitrocamptothecin
Terms in Rubitecan category
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