SARA Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> SARA Protein

SARA Protein Definition

Encoded by MADHIP Gene, ubiquitous cytoplasmic SARA contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Alternate isoforms represent full-length (1425-aa, 156-kD) or truncated protein (1210-aa and 762-aa). Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI)

SARA Protein Synonyms

SARA Protein, MAD (Mothers Against Decapentaplegic, Drosophila) Homolog Interacting Protein, Receptor Activation Anchor, MADH-Interacting Protein, MADHIP, Mothers Against Decapentaplegic Homolog Interacting Protein, NSP, Novel Serine Protease, Receptor Activation Anchor Protein, SMAD Anchor for Receptor Activation, hSARA

SARA Protein

SARA Protein Definition

SARA Protein Synonyms

Terms in SARA Protein category