SH3-Binding Motif

Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Ligand Binding Domain -> Protein Binding Domain -> SH3-Binding Motif

SH3-Binding Motif Definition

Typically found in proteins involved in signaling pathways, the SH3-Binding Motif is a peptide sequence that mediates regulated high-affinity physical interaction (binding) with the SH3 (SRC Homology 3) domain in target protein partners. The SH3-binding motif often share proline-rich stretches containing a common PXXP motif. (NCI)

SH3-Binding Motif Synonyms

SH3-Binding Motif, SH3-Binding Domain

Terms in SH3-Binding Motif category

PXXP Motif