SKI-Like Protein-SKIL

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> SKI-Like Protein-SKIL

SKI-Like Protein-SKIL Definition

SKI-Like Protein SKIL is widely expressed by human SKIL Gene with immediate early kinetics upon serum stimulation as alternative isoforms: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). A component of the TGFB/SMAD pathway, SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling. (NCI)

SKI-Like Protein-SKIL Synonyms

SKI-Like Protein SKIL, SKI-Like, SKI-Related Oncogene SNON Protein, SKI-Related Protein, SKIL, SNO, SNOA, SNON

SKI-Like Protein-SKIL

SKI-Like Protein-SKIL Definition

SKI-Like Protein-SKIL Synonyms

Terms in SKI-Like Protein-SKIL category