Cancer Terms

SN-38-Loaded Polymeric Micelle

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> SN-38-Loaded Polymeric Micelle

SN-38-Loaded Polymeric Micelle Definition

A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded polymeric micelles NK012 is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in an aqueous milieu. SN-38 (7-ethyl-10-hydroxy-camptothecin), a biological active metabolite of the prodrug irinotecan (CPT-11), binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. This formulation increases the water-solubility of SN-38 and allows the delivery of higher doses of SN-38 than those achievable with SN-38 alone.

SN-38-Loaded Polymeric Micelle Synonyms

SN-38-Loaded Polymeric Micelles NK012

Terms in SN-38-Loaded Polymeric Micelle category



Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.