SRC Family Associated Phosphoprotein-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> SRC Family Associated Phosphoprotein-2

SRC Family Associated Phosphoprotein-2 Definition

Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon by human SCAP2 Gene (SRC Kinase Family), 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest, is thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI)

SRC Family Associated Phosphoprotein-2 Synonyms

SRC Family Associated Phosphoprotein 2, FYN-Associated Phosphoprotein SKAP55 Homologue, SAPS, SCAP2, SKAP55-Related Protein, SKAP55R, SRC Kinase-Associated Phosphoprotein of 55-Related Protein, SRC-Associated Adaptor Protein

SRC Family Associated Phosphoprotein-2

SRC Family Associated Phosphoprotein-2 Definition

SRC Family Associated Phosphoprotein-2 Synonyms

Terms in SRC Family Associated Phosphoprotein-2 category