SYK Kinase Inhibitor R-935788
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SYK Kinase Inhibitor R-935788 Definition
An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
SYK Kinase Inhibitor R-935788 Synonyms
Fostamatinib Disodium, 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]- 4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, Disodium Salt, Hexahydrate, R-935788 Sodium, R788 Sodium, SYK Kinase Inhibitor R-935788
Terms in SYK Kinase Inhibitor R-935788 category
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