Cancer Terms

Salirasib

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Signal Transduction Inhibitor -> Ras Inhibitor -> Salirasib

Salirasib Definition

A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.

Salirasib Synonyms

Salirasib, 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic Acid, S-Farnesylthiosalicylic Acid, SALIRASIB

Terms in Salirasib category



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