Cancer Terms

SarCNU

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Nitrosourea Compound -> SarCNU

SarCNU Definition

An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

SarCNU Synonyms

SarCNU, 2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea, sarCNU

Terms in SarCNU category



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