Scaffold Attachment Factor-B

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Structural Protein -> Nuclear Matrix Protein -> Scaffold Attachment Factor-B

Scaffold Attachment Factor-B Definition

Encoded by human SAFB Gene, HET Scaffold Attachment Factor B is a highly charged monomeric 915-amino acid scaffold attachment factor with high S/MAR (Scaffold/Matrix-Associating Region) DNA-binding specificity; scaffold attachment factors A, B, C, and D interact with S/MAR DNA. The protein contains potential phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in thousands of loop domains fixed at their base through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFB is a HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB also interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM and NCI)

Scaffold Attachment Factor-B Synonyms

Scaffold Attachment Factor B, Chromatin-Associated DNA-Binding Protein B, HET, HET Scaffold Attachment Factor B, HET/SAF-B Protein, HSP27 ERE and TATA-Binding Protein, HnRNP A1 Associated Protein, Hsp27-ERE-TATA-Binding Protein, SAFB

Scaffold Attachment Factor-B

Scaffold Attachment Factor-B Definition

Scaffold Attachment Factor-B Synonyms

Terms in Scaffold Attachment Factor-B category