Secreted Frizzled-Related Protein-4
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Secreted Frizzled-Related Protein-4 Definition
Encoded by human SFRP4 Gene (SFRP Family), Secreted Frizzled-Related Protein 4 is a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI)
Secreted Frizzled-Related Protein-4 Synonyms
Secreted Frizzled-Related Protein 4, FRPHE, Frizzled-Related Protein, SFRP4
Terms in Secreted Frizzled-Related Protein-4 category
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