Selegiline Hydrochloride
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Monoamine Oxidase Inhibitor -> Selegiline Hydrochloride
Selegiline Hydrochloride Definition
The hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO) inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by MAO B, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron and prolong dopamine activity.
Selegiline Hydrochloride Synonyms
Selegiline Hydrochloride, Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, Hydrochloride,(R)-, Eldepryl, Emsam, L-deprenyl Hydrochloride, SELEGILINE HYDROCHLORIDE
Terms in Selegiline Hydrochloride category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.