Semustine
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Nitrosourea Compound -> Semustine
Semustine Definition
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
Semustine Synonyms
Semustine, 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea, 1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosourea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Lomustine, Methyl, Lomustine, methyl, MCCNU, MeCCNU, Methyl CCNU, Methyl Lomustine, Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI), Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI), methyl-CCNU, semustine, trans-Methyl-CCNU, urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI), urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)
Terms in Semustine category
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