Serine Protease Inhibitor WX-671
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Serine Protease Inhibitor WX-671 Definition
An orally active, 3-amidinophenylalanine-derived, second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. After oral administration, serine protease inhibitor WX-671 is converted to the active N-(2,4,6-triisopropylphenylsulfonyl)-3-amidino-(L)-phenylalanine-4-ethoxycarbonylpiperazide (WX-UK1), which inhibits several serine proteases, particularly uPA; inhibition of uPA may result in the inhibition of tumor growth and metastasis. uPA is a serine protease involved in degradation of the extracellular matrix and tumor cell migration and proliferation.
Serine Protease Inhibitor WX-671 Synonyms
Serine Protease Inhibitor WX-671, WX-671
Terms in Serine Protease Inhibitor WX-671 category
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