Cancer Terms

Serine Threonine Kinase Inhibitor XL418

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Serine Threonine Kinase Inhibitor -> Serine Threonine Kinase Inhibitor XL418

Serine Threonine Kinase Inhibitor XL418 Definition

A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.

Serine Threonine Kinase Inhibitor XL418 Synonyms

Serine/Threonine Kinase Inhibitor XL418, XL418

Terms in Serine Threonine Kinase Inhibitor XL418 category



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