Sex Hormone-Binding Globulin
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Ligand Binding Protein -> Sex Hormone-Binding Globulin
Sex Hormone-Binding Globulin Definition
Expressed as 2 alternative isoforms in Sertoli cells and liver by human SHBG Gene, 402-aa 44-kDa (precursor) homodimeric Sex Hormone-Binding Globulin is a secreted beta-globulin plasma glycoprotein containing 2 laminin G-like domains that specifically bind 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)
Sex Hormone-Binding Globulin Synonyms
Sex Hormone-Binding Globulin, ABP, Androgen-Binding Protein, SHBG, Sex Steroid-Binding Protein, Testis-Specific Androgen-Binding Protein, Testosterone Estradiol Binding Globulin
Terms in Sex Hormone-Binding Globulin category
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