Signal Transducer and Activator of Transcription Family Gene

Cancer Terms -> Gene -> Regulatory Gene -> Transcription Coregulator Gene -> Transcription Coactivator Gene -> Signal Transducer and Activator of Transcription Family Gene

Signal Transducer and Activator of Transcription Family Gene Definition

Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI)

Signal Transducer and Activator of Transcription Family Gene Synonyms

Signal Transducer and Activator of Transcription Family Gene, STAT Family Gene

Terms in Signal Transducer and Activator of Transcription Family Gene category

STAT1 Gene
STAT2 Gene
STAT3 Gene
STAT4 Gene
STAT5A Gene
STAT5B Gene
STAT6 Gene