Smoothened Homolog Protein
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Ligand Binding Protein ->
Receptor ->
Cell Surface Receptor ->
G Protein-Coupled Receptor -> Smoothened Homolog Protein
Smoothened Homolog Protein Definition
Encoded by human SMO Gene (FZ/SMO GPCR Family), 787-aa 86-kDa (precursor) Smoothened Homolog is a 7-transmembrane G protein-coupled receptor containing 1 FZ domain that seems to form a complex with PTCH to transduce the SHH signal. SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by PTCH and to activate target gene transcription. Sonic Hedgehog Homolog is the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. SMO defects are involved in BCC. (NCI)
Smoothened Homolog Protein Synonyms
Smoothened Homolog, Gx Protein, SMO, SMOH, Smoothened
Terms in Smoothened Homolog Protein category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.