Soluble Guanylate Cyclase-1-Alpha-2
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Protein Complex Subunit -> Soluble Guanylate Cyclase-1-Alpha-2
Soluble Guanylate Cyclase-1-Alpha-2 Definition
Expressed as alternative isoforms in testis and fetal brain (Isoform 1), and in liver, colon, and endothelium (Isoform 1, 2) by human GUCY1A2 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family), cytoplasmic Soluble Guanylate Cyclase 1 Alpha 2 is a subunit of nitric oxide-activated heterodimeric (alpha/beta) soluble guanylate cyclases that catalyze conversion of GTP to cGMP second messenger. With regions of high similarity to alpha-1, GUCY1A2 exhibits guanylyl cyclase activity on binding to the beta subunit. Isoform alpha-2-I acts as a negative guanylyl cylase regulator; forming non-functional heterodimers with beta subunits. (NCI)
Soluble Guanylate Cyclase-1-Alpha-2 Synonyms
Soluble Guanylate Cyclase 1 Alpha 2, GCS-Alpha-2, GUCY1A2, Soluble Guanylate Cyclase 1A2, Soluble Guanylate Cyclase Alpha-2 Chain
Terms in Soluble Guanylate Cyclase-1-Alpha-2 category
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