Sorivudine
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Sorivudine Definition
A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market.
Sorivudine Synonyms
Sorivudine, (+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil, (E)-1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione, 1-Beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil, 2,4(1H,3H)-pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl), 5-(2-bromovinyl)-1-beta-D- arabinofuranosyluracil, 5-Bromovinyl-araU, BV-araU, Bravavir, SQ 32756, Usevir, YN-72
Terms in Sorivudine category
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