Cancer Terms

Spleen Tyrosine Kinase

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Spleen Tyrosine Kinase Definition

Related to B cell activation, PTK72 is a tyrosine kinase that becomes tyrosine phosphorylated and activated soon after anti-Ig stimulation of B cells. It is found associated with the mIg receptor complex. Unlike the membrane-bound Src-family tyrosine kinases, PTK72 is primarily present as a soluble cytosolic protein. It is probably the product of the syk gene and is highly related to the ZAP-70 protein associated with T cell activation.

Spleen Tyrosine Kinase Synonyms

Spleen Tyrosine Kinase, 2.7.1.112, PTK72, PTK72 Protein, SYK, Tyrosine-Protein Kinase SYK

Terms in Spleen Tyrosine Kinase category



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