Cancer Terms

Stromal Interaction Molecule-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Location -> Membrane Protein -> Transmembrane Protein -> Stromal Interaction Molecule-1

Stromal Interaction Molecule-1 Definition

Encoded by human STIM1 Gene, ubiquitously expressed 685-amino acid 77.5 kD (precursor) Stromal Interaction Molecule 1 Protein is a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (NCI)

Stromal Interaction Molecule-1 Synonyms

Stromal Interaction Molecule 1, STIM1

Terms in Stromal Interaction Molecule-1 category



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