Stromal Interaction Molecule-1
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Stromal Interaction Molecule-1 Definition
Encoded by human STIM1 Gene, ubiquitously expressed 685-amino acid 77.5 kD (precursor) Stromal Interaction Molecule 1 Protein is a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (NCI)
Stromal Interaction Molecule-1 Synonyms
Stromal Interaction Molecule 1, STIM1
Terms in Stromal Interaction Molecule-1 category
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