Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase

Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase Definition

An intravenous formulation containing E.coli-derived L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (SC-PEG), with potential antineoplastic activity. L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cells of asparagine; asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death. Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Pegylation decreases enzyme antigenicity and increases its half life. SC is used as a PEG linker to facilitate attachment to asparaginase and enhances the stability of the formulation.

Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase Synonyms

SC-PEG E. Coli L-Asparaginase, EZN-2285, Oncaspar-IV, Succinimidyl Carbonate Monomethoxypolyethylene Glycol E. coli L-Asparaginase

Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase

Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase Definition

Succinimidyl Carbonate Monomethoxypolyethylene Glycol E Coli L-Asparaginase Synonyms

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