A class of natural or synthetic sulfanilamide derivatives with antibacterial activity. Sulfonamides are structural analogues of para-aminobenzoic acid (essential for microbial folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA for dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.
Sulfonamide Anti-infective Agent Synonyms
Sulfonamide Anti-infective Agent, Sulfonamides
Terms in Sulfonamide Anti-infective Agent category