Suppressor of Cytokine Signaling Family Gene

Cancer Terms -> Gene -> Regulatory Gene -> Suppressor of Cytokine Signaling Family Gene

Suppressor of Cytokine Signaling Family Gene Definition

Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)

Suppressor of Cytokine Signaling Family Gene Synonyms

Suppressor of Cytokine Signaling Family Gene, CIS Family Gene, Cytokine-Induced STAT Inhibitor Family Gene, SOCS Family Gene, SSI Family Gene, STAT-Induced STAT Inhibitor Family Gene

Terms in Suppressor of Cytokine Signaling Family Gene category

CISH Gene