Suramin Sodium
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Suramin Sodium Definition
A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
Suramin Sodium Synonyms
Suramin Sodium, 309 F, 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt, Antrypol, Bayer 205, Belganyl, CI-1003, Fourneau 309, Germanin, Metaret, Moranyl, Naganin, Naganinum, Naganol, Naphuride, Sodium Suramin, Sodium suramin, Suramin Hexasodium, Suramin sodium
Terms in Suramin Sodium category
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