T-Cell Acute Lymphocytic Leukemia-2 Protein
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T-Cell Acute Lymphocytic Leukemia-2 Protein Definition
Encoded by human TAL2 Gene, 108-aa 12-kDa bHLH T-Cell Acute Lymphocytic Leukemia 2 Protein has sequence homology to TAL1 and LYL1, bHLH proteins involved in T-cell leukemogenesis. TAL2 also includes a DNA-binding domain homologous to those in TAL1 and LYL1. A T-ALL translocation, t(7;9)(q34;q32), results from a mistake during V(D)J recombination using a fortuitous 3-prime TAL2 recombination site and the TCRB J-beta-2 coding segment that juxtaposes TAL2 with the TCR-beta enhancer and results in TAL2 overexpression. (NCI)
T-Cell Acute Lymphocytic Leukemia-2 Protein Synonyms
T-Cell Acute Lymphocytic Leukemia 2 Protein, T-Cell Acute Lymphocytic Leukemia 2, TAL2, TAL2 Protein
Terms in T-Cell Acute Lymphocytic Leukemia-2 Protein category
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