T-Cell Development

Cancer Terms -> Biological Process -> Multicellular Process -> Developmental Process -> Cell Differentiation Process -> Cell Differentiation -> T-Cell Development

T-Cell Development Definition

Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP)

T-Cell Development Synonyms

T-Cell Development, T-Cell Ontogeny, T-Lymphocyte Development

Terms in T-Cell Development category

Thymocyte Development