T-Cell Receptor

Cancer Terms -> Gene Product -> Protein or Riboprotein Complex -> T-Cell Receptor

T-Cell Receptor Definition

Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins. Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression. Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products. T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands. T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex. TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. (from OMIM and NCI)

T-Cell Receptor Synonyms

T-Cell Receptor, MHC Receptor, Major Histocompatibility Complex Receptor, TCR

Terms in T-Cell Receptor category

T-Cell Receptor Alpha-Beta
T-Cell Receptor Gamma-Delta