T-Cell Receptor Alpha Locus
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T-Cell Receptor Alpha Locus Definition
This region represents the germline organization of the T cell receptor alpha locus. The alpha locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the alpha chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)
T-Cell Receptor Alpha Locus Synonyms
T-Cell Receptor Alpha Locus, T-Cell Receptor Alpha Gene, TCRA, TRA
Terms in T-Cell Receptor Alpha Locus category
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