T138067
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T138067 Definition
A synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. (NCI04)
T138067 Synonyms
T138067 Sodium, 2-Fluoro-1-methoxy-4-(pentafluorophenyl-sulfonamido)benzene, Sodium Salt, 2-Fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene, T138067
Terms in T138067 category
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