TAC-101
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TAC-101 Definition
A retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression. (NCI04)
TAC-101 Synonyms
Amsilarotene, AMSILAROTENE, TAC 101, TAC-101
Terms in TAC-101 category
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