TAT-Interacting Protein-TIP30
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TAT-Interacting Protein-TIP30 Definition
Encoded by human HTATIP2 Gene (SDR Family), the ubiquitous 242-amino acid 30-kD TAT-Interacting Protein TIP30 is a nuclear and membrane-associated tumor suppressor that contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a 20-amino acid N-terminal alpha helix that may enable protein docking. Proapoptotic TIP30 activity resides in the N-terminal domain. A 133-amino acid membrane-associated variant TC3 Protein contains a unique short C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
TAT-Interacting Protein-TIP30 Synonyms
TAT-Interacting Protein TIP30, HIV-1 TAT Interactive Protein 2, 30-kD, HIV-1 TAT-Interacting Protein 30-kD, HTATIP2, HTATIP2 Protein, TAT-Interacting Protein (30kD)
Terms in TAT-Interacting Protein-TIP30 category
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