TATA-Binding Protein-Associated Phosphoprotein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> TATA-Binding Protein-Associated Phosphoprotein

TATA-Binding Protein-Associated Phosphoprotein Definition

Encoded by human DR1 Gene, TATA-Binding Protein-Associated Phosphoprotein represses both basal and activated levels of transcription. DR1 phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region and represses transcription with DRAP1 by inhibiting pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. (NCI)

TATA-Binding Protein-Associated Phosphoprotein Synonyms

TATA-Binding Protein-Associated Phosphoprotein, DR1 Protein, Down-Regulator of Transcription 1, Downregulator of Transcription 1 TBP-Binding DR1, NC2-Beta, Negative Cofactor 2-Beta, TATA Box-Binding Protein-Associated Phosphoprotein DR1

TATA-Binding Protein-Associated Phosphoprotein

TATA-Binding Protein-Associated Phosphoprotein Definition

TATA-Binding Protein-Associated Phosphoprotein Synonyms

Terms in TATA-Binding Protein-Associated Phosphoprotein category