TBP-Associated Factor-140kDa
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Protein ->
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Transcription Regulatory Protein ->
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Basal Transcription Factor -> TBP-Associated Factor-140kDa
TBP-Associated Factor-140kDa Definition
Encoded by human TAF3 Gene, 140-kD nuclear TBP-Associated Factor 140kDa apparently forms complexes with TBP, TAF10, and TAF13, as well as with SAP130 and GCN5. TAF3 contains an N-terminal HFD (interacts with TAF10) and is highly homologous to mouse Tafii140; a PHD finger motif is likely present. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
TBP-Associated Factor-140kDa Synonyms
TBP-Associated Factor 140kDa, RNA Polymerase II Transcription Factor TAFII140, TAF140, TAF3, TAF3 RNA Polymerase II, TAFII140, TATA Box Binding Protein-Associated Factor 140kDa
Terms in TBP-Associated Factor-140kDa category
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