TBP-Associated Factor-15kDa

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> TBP-Associated Factor-15kDa

TBP-Associated Factor-15kDa Definition

Ubiquitously expressed as alternative initiation isoforms by human TAF12 Gene (TAF2J Family), nuclear (18-kDa precursor) TBP-Associated Factor 15 kDa and 20 kDa, similar to Histones H2B and H3, are components of the TFIID complex essential for regulation of transcription. A component of the PCAF complex and the STAGA transcription coactivator-HAT complex, TAF12 interacts directly with TBP and TAF11, as well as with TAFII20 and TAFII30. TFIID is composed of TBP and many TAF proteins. Control of transcription by the RNA polymerase II basal transcription machinery complex is modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to transcription start sites. Some modulators interact directly with the basal complex; others may bridge transactivators to the basal factors. Different TAFs may mediate distinct transcriptional activators. (NCI)

TBP-Associated Factor-15kDa Synonyms

TBP-Associated Factor 15 kDa, TAF12, TAF12 RNA Polymerase II, TAF2J, TAFII15, TATA Box Binding Protein-Associated Factor 15 kDa, Transcription Initiation Factor TFIID 15 kDa Subunit

TBP-Associated Factor-15kDa

TBP-Associated Factor-15kDa Definition

TBP-Associated Factor-15kDa Synonyms

Terms in TBP-Associated Factor-15kDa category