TBP-Associated Factor-4

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> TBP-Associated Factor-4

TBP-Associated Factor-4 Definition

Encoded by human TAF4 Gene (TAF2C Family), 1083-aa 110-kDa nuclear TBP-Associated Factor 4, containing 1 TAFH/NHR1 domain, is one of the larger subunits of the multimeric TFIID complex that mediates promoter responses to various activators and repressors. A component of the TFTC-HAT complex, TAF4 interacts with transcription factor CREB and other proteins containing glutamine-rich regions and potentiates transcriptional activation by the AF-2S of the RAR, THR and vitamin D3 receptor. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)

TBP-Associated Factor-4 Synonyms

TBP-Associated Factor 4, TAF2C, TAF2C1, TAF4, TAF4 RNA Polymerase II, TAF4A, TAFII130, TAFII135, TATA Box Binding Protein-Associated Factor 135 kD, TATA Box Binding Protein-Associated Factor RNA Polymerase II C1 130kD, TBP-Associated Factor 135 kD, TBP-Associated Factor RNA Polymerase II C1 130kD, Transcription Initiation Factor TFIID 135 kDa Subunit

TBP-Associated Factor-4

TBP-Associated Factor-4 Definition

TBP-Associated Factor-4 Synonyms

Terms in TBP-Associated Factor-4 category