TBP-Associated Factor-5

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> TBP-Associated Factor-5

TBP-Associated Factor-5 Definition

Encoded by human TAF5 Gene, alternative 745-aa and 800-aa 87-kDa isoforms of nuclear TBP-Associated Factor 5 interact strongly with (histone H4-related) TAFII80 and (histone H3-related) TAFII31, as well as with TBP, TAFII250, TAFII28, and TAFII20. A component of the TFTC-HAT complex, TAFII100 contains 1 LisH domain and 6 WD repeats; distinct TAFII100 domains are required for interaction with TFIIFB and for incorporation into TFIID. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)

TBP-Associated Factor-5 Synonyms

TBP-Associated Factor 5, TAF2D, TAF5, TAF5 RNA Polymerase II, TAFII100, TATA Box Binding Protein-Associated Factor, TATA Box Binding Protein-Associated Factor 100kDa, TATA Box Binding Protein-Associated Factor RNA Polymerase II D 100kD, TBP-Associated Factor 100kDa, TBP-Associated Factor 2D, TBP-Associated Factor RNA Polymerase II D 100kD, Transcription Initiation Factor TFIID 100 kD Subunit

TBP-Associated Factor-5

TBP-Associated Factor-5 Definition

TBP-Associated Factor-5 Synonyms

Terms in TBP-Associated Factor-5 category