TBP-Associated Factor-6

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> TBP-Associated Factor-6

TBP-Associated Factor-6 Definition

Encoded by human TAF6 Gene (TAF2E Family), 677-aa 73-kDa nuclear TBP-Associated Factor 6, one of the smaller TFIID subunits, binds tightly to TAF1 (the largest subunit of TFIID) to TBP, and directly to TAFII40. Four isoforms have been identified; one isoform precludes binding of another TFIID subunit, reducing transcription and initiating apoptotic signals. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)

TBP-Associated Factor-6 Synonyms

TBP-Associated Factor 6, TAF2E, TAF6, TAF6 RNA Polymerase II, TAFII70, TAFII80, TAFII85, TATA Box Binding Protein-Associated Factor 80kDa, TATA Box Binding Protein-Associated Factor RNA Polymerase II E 70/85kD, TBP-Associated Factor 80kDa, TBP-Associated Factor RNA Polymerase II E 70/85kD, Transcription Initiation Factor TFIID 70 kD Subunit

TBP-Associated Factor-6

TBP-Associated Factor-6 Definition

TBP-Associated Factor-6 Synonyms

Terms in TBP-Associated Factor-6 category