TCR Activation
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TCR Activation Definition
TCR Activation during T cell development and proliferation involves binding to specific antigen by Ig-like heterodimeric transmembrane surface alpha/beta (antigen/MHC) or gamma/delta (antigen) glycoprotein receptors non-covalently associated with CD3 complex on T lymphocytes. Antigen-bound TCRs activate MAPKs and JNK1 through CD3 antigens, adaptor protein LAT, and tyrosine kinases LCK and ZAP70.
TCR Activation Synonyms
TCR Activation, T-Cell Receptor Interaction, TCR Interaction
Terms in TCR Activation category
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