TEK Tyrosine Kinase
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TEK Tyrosine Kinase Definition
Encoded by human TEK Gene (TIE Family) and expressed predominantly in endothelia and angioblasts, TEK Tyrosine Kinase receptor is a type I transmembrane protein closely related to the TIE receptor. With a unique extracellular domain containing 2 Ig-like C2 domains separated by 3 EGF-like domains connected to 3 FN III-like domains, the ANG1 and ANG2 receptor TEK is important in angiogenesis, endothelial cell proliferation and differentiation, and endothelial cell patterning during vascular morphogenesis. TEK may constitute a mammalian endothelial cell lineage marker. Activating defects and deficiencies in TEK are associated with venous malformations (VMCM). (from LocusLink, Swiss-Prot, OMIM, and NCI)
TEK Tyrosine Kinase Synonyms
TEK Tyrosine Kinase, Angiopoietin 1 Receptor, CD202B Antigen, Endothelial TEK Tyrosine Kinase, Epithelial-Specific Protein Receptor Tyrosine Kinase TIE-2, TEK Tyrosine Kinase, Endothelial, Tunica Interna Endothelial Cell Kinase, Tyrosine-Protein Kinase Receptor TEK, Tyrosine-Protein Kinase Receptor TIE-2, p140 TEK
Terms in TEK Tyrosine Kinase category
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