TFIIE Subunit Gene

Cancer Terms -> Gene -> Transcription Factor Gene -> Basal Transcription Factor Gene -> TFIIE Subunit Gene

TFIIE Subunit Gene Definition

TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level transcription. Both subunits are essential to form a stable preinitiation complex. High levels of gene transcription by RNA polymerase II depend on high rates of transcription initiation and reinitiation. Initiation requires recruitment of the complete transcription machinery to a promoter, a process facilitated by activators and chromatin remodeling factors. Reinitiation occurs through a different pathway. After initiation, a subset of the transcription machinery remains at the promoter, forming a platform for assembly of a second transcription complex as a scaffold for formation of a functional reinitiation complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and Mediator may promote high levels of transcription. (from OMIM 189962).

TFIIE Subunit Gene Synonyms

TFIIE Subunit Gene

Terms in TFIIE Subunit Gene category

GTF2E1 Gene
GTF2E2 Gene