TLK199
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Glutathione Transferase Inhibitor -> TLK199
TLK199 Definition
A liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of TLK199 (TLK117) binds to and inhibits GST P1-1, thereby restoring Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation pathways. This agent promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets.
TLK199 Synonyms
Ezatiostat Hydrochloride, EZATIOSTAT HYDROCHLORIDE, TER199, TLK199, Telintra
Terms in TLK199 category
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