Cancer Terms

TLK286

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Mustard Agent -> Mustard Prodrug -> TLK286

TLK286 Definition

A modified glutathione analog. TLK286 is selectively activated by glutathione S-Transferase P1-1 into an alkylating metabolite which forms covalent linkages with nucleophillic centers in tumor cell DNA, thereby inducing a cellular stress response and cytotoxicity, and decreasing tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. (NCI04)

TLK286 Synonyms

TLK286, CANFOSFAMIDE HYDROCHLORIDE

Terms in TLK286 category



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