TNF Receptor Family Protein
Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> TNF Receptor Family Protein
TNF Receptor Family Protein Definition
Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366)TNF Receptor Family Protein Synonyms
TNF Receptor Family Protein, TNF Receptor, TNF Receptor Superfamily, TNFR, Tumor Necrosis Factor Receptor, Tumor Necrosis Factor Receptor Family, Tumor Necrosis Factor Receptor SuperfamilyTerms in TNF Receptor Family Protein category
CD40L ReceptorFAS Antigen
FAS Ligand Decoy Receptor
Osteoprotegerin
TNF Receptor-8
TRAIL Receptor-1
TRAIL Receptor-2
Tumor Necrosis Factor Alpha Receptor
Tumor Necrosis Factor Beta Receptor