Cancer Terms

TNF Receptor-8

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> TNF Receptor Family Protein -> TNF Receptor-8

TNF Receptor-8 Definition

Expressed in activated T- and B-cells by human TNFRSF8 Gene (TNFR Superfamily) as distinct serine and tyrosine phosphorylated Long (595-aa, 64-kDa precursor type I membrane protein) and Short (cytoplasmic) isoforms, TNF Receptor 8 contains 6 TNFR-Cys repeats. A positive regulator of apoptosis and receptor for TNFSF8/CD30L, TNFRSF8 interacts with the TRAF1, TRAF2, TRAF3, and TRAF5 mediators of signal transduction and regulates gene expression through NF-Kappa-B activation. A Hodgkin's disease associated antigen, TNFRSF8 limits the proliferative potential of autoreactive CD8 effector T cells and protects against autoimmunity. (NCI)

TNF Receptor-8 Synonyms

TNF Receptor 8, CD30 Antigen

Terms in TNF Receptor-8 category



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